H2N2V1, Main, Exploration, bibRecord, 000B92

Why Do Influenza Virus Subtypes Die Out? A Hypothesis

Identifieur interne : 000B92 ( Main/Exploration ); précédent : 000B91; suivant : 000B93

Why Do Influenza Virus Subtypes Die Out? A Hypothesis

Auteurs : Peter Palese ; Taia T. Wang

Source :

mBio [ 2150-7511 ] ; 2011.

RBID : PMC:3163940

Abstract

ABSTRACT

Novel pandemic influenza viruses enter the human population with some regularity and can cause disease that is severe and widespread. The emergence of novel viruses, historically, has often been coupled with the disappearance of existing seasonal virus strains. Here, we propose that the elimination of seasonal strains during virus pandemics is a process mediated, at the population level, by humoral immunity. Specifically, we suggest that infection with a novel virus strain, in people previously exposed to influenza viruses, can elicit a memory B cell response against conserved hemagglutinin stalk epitopes and/or neuraminidase epitopes. The anti-stalk and/or anti-neuraminidase antibodies then act to diminish the clinical severity of disease caused by novel influenza viruses and to eliminate seasonal virus strains.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163940

DOI: 10.1128/mBio.00150-11
PubMed: 21878571
PubMed Central: 3163940

Affiliations:

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Serveur d'exploration H2N2

Why Do Influenza Virus Subtypes Die Out? A Hypothesis

Why Do Influenza Virus Subtypes Die Out? A Hypothesis

Source :

Abstract

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Le document en format XML

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